Matt Kaeberlein

Dr. Kaeberlein completed his Ph.D. in the laboratory of Leonard Guarente at M.I.T., where he discovered the key role of SIR2 as a regulator of yeast life span. Dr. Kaeberlein is a co-founder of Longenity Inc., where he developed high-throughput gene expression and proteomic technologies for the identification of biomarkers of aging and age-associated disease. At the University of Washington, Dr. Kaeberlein has co-developed technologies that will facilitate a rapid and comprehensive analysis of the chronological and replicative aging properties for every non-essential gene in the yeast genome. Dr. Kaeberlein is also a contributor to Science Magazine’s Science of Aging Knowledge Environment (SAGE KE), where he created and curates the Aging Genes/Interventions Database.

• Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD,
  Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK.
  Substrate-specific activation of sirtuins by resveratrol.
  J Biol Chem. 2005 Apr 29;280(17):17038-45. Epub 2005 Jan 31.
  PMID: 15684413 [PubMed - in process]

• Kaeberlein M, Kirkland KT, Fields S, Kennedy BK.
  Sir2-independent life span extension by calorie restriction in yeast.
  PLoS Biol. 2004 Sep;2(9):E296. Epub 2004 Aug 24.
  PMID: 15328540 [PubMed - in process